Encyclopedia of Life Sciences Antigens: Lipids Kazuhiro Matsuda Research and Development, M Bio Technology, Inc., Tokyo, Japan.
Molecular mechanisms of lipid-antigen recognition are important in the frontier of immunology. Possible pathogeneses of autoimmune diseases and tumours now include infections with microorganisms. Therefore, the role of vaccines is increasingly important, as advancing technology has now broadened the targets of vaccination to include a greater number of infectious diseases, tumours, chronic infections, autoimmune diseases and allergies. In order to prevent infectious diseases through vaccination, it is important to identify specific antigens which often exist in the cell membrane and capsule and also become the centre of host-pathogen interactions. Structural analysis of lipid-antigens is critical for understanding the mechanisms of molecular interactions involved in the pathogenesis of immune abnormalities, and for devising strategies surrounding immune system regulation and drug discovery. (This article has been accepted and will be published at 2011.12.15.) eLS is published by John Wiley and Sons Ltd.
*eLS (formerly known as the Encyclopedia of Life Sciences) is a monthly-updating reference work containing over 4800 specially commissioned, peer-reviewed and citable articles written by leaders in the field
Symposium (S3-5) : NOVEL SERODIAGNOSIS OF MYCOPLASMA INFECTIOUS DISEASES BASED ON LIPID-ANTIGEN TECHNOLOGIES. Kazuhiro Matsuda M Bio Technology Inc./ Keio University School of Medicine March. 27-29, 2012 Nagasaki, JAPAN
・Early diagnosis of Mycoplasma pneumonie infection is important to prevent because of the appearance of antibiotics resistant mycoplasma, and also from the viewpoint of medical economics ・New ELISA which utilize chemically synthesized mycoplasma species-specific lipid-antigen (anti- GGL Glc-type ELISAs ) are superior to conventional methods. ・In child patients, the anti-GGL Glc-type ELISA (IgM ) is much more suitable for the rapid early diagnosis of M pneumoniae infection than currently available conventional serological methods, and also anti-GGL Glc-type ELISA (IgG ) reflect the status of infection. ・In adult patients, the anti-GGL Glc-type ELISAs (IgM /IgG/IgA) are available to diagnose Mycoplasma pneumoniae infection suitable for the early diagnosis of M pneumoniae infection and follow the clinical course quantitatively. ・The anti-GGL Glc-type ELISAs enable the studies for the links to chronic diseases, extrapulmonary diseases, and possibly M. pneumoniae infection-related disease, such as asthma rheumatoid arthritis.
Synthetic glycolipid antigens (GGL) for medicinal applications against Mycoplasma pneumoniae infection Kazuo Fukuda1, Hirofumi Dohi1, Sachie Matsuda2, Kazuhiro Matsuda2, Yoshihiro Nishida1, 1Chiba University, 2 M Bio Technology Inc.
Recently, we determined the chemical structure of β-glycoglycerolipid antigens isolated from the cell-membrane of Mycoplasma pneumoniae. These glycolipids serve as a species-specific immunodeterminant of this pathogenic bacteria and thus have a high medicinal potential. In the present study, we performed stereoselective synthesis for a series of glycolipid having different fatty acid chains by using our non-malodorous thioglycosylation methodology. Furthermore, immunostaining-assay and ELISA-assay were conducted for each of these homologues.
Symposium II : Recent clinical topics and issues of Mycoplasma pneumoniae pneumonia. Is it Possible to Diagnose Mycoplasma pneumonie infection Earlier? Kazuhiro Matsuda October 19-21, 2011 Nagasaki, JAPAN. Joint Congress of 5th AOM & 38th JSM
Novel Technologies for Mycoplasma Lipid-antigen Discovery and Vaccine Development. 18th Congress of The International Organization for Mycoplasmology. (2010) Matsuda, K.
Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis. 18th Congress of The International Organization for Mycoplasmology. (2010) Kawahito, Y., Ichinose, S., Sano, H., Tsubouchi, Y., Kohno, M., Yoshikawa, T., Tokunaga, D., Hojo, T., Harasawa, R., Nakano, T., Matsuda, K.
Efforts to demonstrate the effectiveness of tetracycline therapy were initiated and first reported over 40 years ago by Thomas McPherson Brown, M.D. Two weeks after Brown's death in 1989, NIH requested grant applications for the controlled clinical trials of tetracycline therapy for rheumatoid arthritis which he had been seeking. The preliminary results of the clinical trials, known now as MIRA or Minocycline in Rheumatoid Arthritis, were promising and the NIH requested grant applications for studies of mycoplasma and other infectious agents as causes for rheumatoid diseases in 1993, and a pilot study for intravenous antibiotics for rheumatoid arthritis in 1994.
The result of the MIRA clinical trial stated, "Patients who suffer from mild to moderate RA now have the choice of another therapeutic agent. Not only did the antibiotic significantly reduce symptoms, but side effects were minimal and less severe than observed for most other common rheumatoid treatments".
According to the American College of Rheumatology, "Minocycline is prescribed for patients with symptoms of mild rheumatoid arthritis. It is sometimes combined with other medications to treat patients with persistent symptoms of this form of arthritis."
Road Back Foundation
The Road Back Foundation's (RBF) Website includes information and support regarding an important and often overlooked treatment option for rheumatic and related diseases. The particular focus here is antibiotic therapy, proven safe and effective in NIH-sponsored clinical trials.
Thousands of patients have reported successfully using antibiotics for conditions including rheumatoid arthritis, scleroderma, juvenile rheumatoid arthritis, lupus, dermatomyositis, ankylosing spondylitis, Lyme disease, Reiter's syndrome, mixed connective tissue disease, fibromyalgia and psoriatic arthritis.
Mycoplasmas (except M. pneumoniae) are usually commensal respiratory and urogenital tract inhabitants, but they can become pathogenic(4). M. orale and M. salivarium , usually commensals of the oro-pharynx, may be found in the lower respiratory tract of patients with chronic bronchitis, although it is not clear that they have an effect on severity of bronchitis(2). M. salivarium has been found in a biofilm of an occluded biliary stent and is implicated in periodontal disease(8,9). This pathogen may also cause arthritis in cases of hypogammaglobulinemia(4). M. fermentans is a co-factor of HIV and may cause lung and brain infection in AIDS patients(10). M. fermentans is also detected in patients with inflammatory arthritic disorders, gulf war syndrome.
Taylor-Robinson, D., & Bebear, C. (1997). Antibiotic susceptibilities of mycoplasmas and treatment of mycoplasmal infections. Journal of Antimicrobial Chemotherapy, 40 (5), 622. Eskow, E., Adelson, M. E., Rao, R. V. S., & Mordechai, E. (2003). Evidence for disseminated Mycoplasma fermentans in New Jersey residents with antecedent tick attachment and subsequent musculoskeletal symptoms. JCR: Journal of Clinical Rheumatology, 9 (2), 77.
The World Health Organization (WHO) supports the development and distribution of safe and effective vaccines, pharmaceutical diagnostics, and drugs, such as through the Expanded Program on Immunization.
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
The Food and Drug Administration (FDA or USFDA) is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments. The FDA is responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), veterinary products, and cosmetics.
The National Institutes of Health (NIH) is one of the world's foremost medical research centers. NIH is made up of 27 Institutes and Centers, each with a specific research agenda, often focusing on particular diseases or body systems.
The National Institute of Allergy and Infectious Diseases (NIAID) conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.
The American College of Rheumatology is an organization of and for physicians, health professionals, and scientists that advances rheumatology through programs of education, research, advocacy and practice support that foster excellence in the care of people with arthritis and rheumatic and musculoskeletal diseases.
The European League Against Rheumatism is an international organisation in the field of rheumatology. The society publishes a medical journal, the Annals of the Rheumatic Diseases, and organises an annual scientific meeting, the Annual European Congress of Rheumatology.
The aims of EULAR are to reduce the burden of rheumatic diseases on the individual and society and to improve the treatment, prevention and rehabilitation of musculoskeletal diseases. To this end, EULAR fosters excellence in education and research in the field of rheumatology. It promotes the translation of research advances into daily care and fights for the recognition of the needs of people with rheumatic diseases.
The American Association for Clinical Chemistry AACC is an international society comprised of medical professionals with an interest in clinical chemistry, clinical laboratory science, and laboratory medicine.
It is important to understand what triggers your symptoms and what makes them go away. Common asthma triggers include: Many people with asthma have allergies, which can trigger asthma symptoms. Tobacco smoke, which is an irritant that often aggravates asthma.Viral and bacterial infections such as the common cold and sinusitis.
The American Society of Hematology (ASH) is the world’s largest professional society concerned with the causes and treatments of blood disorders. The mission of the Society is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and the immunologic, hemostatic and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology.